Multivalent weak interactions between assembly units drive synaptonemal complex formation
نویسندگان
چکیده
منابع مشابه
The Ecm11-Gmc2 Complex Promotes Synaptonemal Complex Formation through Assembly of Transverse Filaments in Budding Yeast
During meiosis, homologous chromosomes pair at close proximity to form the synaptonemal complex (SC). This association is mediated by transverse filament proteins that hold the axes of homologous chromosomes together along their entire length. Transverse filament proteins are highly aggregative and can form an aberrant aggregate called the polycomplex that is unassociated with chromosomes. Here...
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During meiosis, a specialized chromosome structure is assembled to promote pairing/ synapsis of homologous chromosomes and meiotic recombination, a process yielding chiasmata between homologs to ensure accurate segregation. Meiosis-specific cohesin complexes mediating sister chromatid cohesion play pivotal roles in almost all these events, including synaptonemal complex (SC) formation. In this ...
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The yeast Zip1 protein is a component of the synaptonemal complex (SC), which is an elaborate macromolecular structure found along the lengths of chromosomes during meiosis. Mutations that increase the length of the predicted coiled coil region of the Zip1 protein show that Zip1 influences the width of the SC. Overexpression of the ZIP1 gene results in the formation of two distinct types of hig...
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Explicit formulae are derived for the calculation of dispersion energies between large molecules, at various levels of approximmion. The derivation introduces frequency-dependent polarizabilities (FDPs), whiCh describe the propagation of electron density fluctuat· ions within each of the separate molecules, but avoids the usual multipole expansion. The resultant dispersion energy formula reveal...
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Biological systems exhibit complex patterns at length scales ranging from the molecular to the organismic. Along chromosomes, events often occur stochastically at different positions in different nuclei but nonetheless tend to be relatively evenly spaced. Examples include replication origin firings, formation of chromatin loops along chromosome axes and, during meiosis, localization of crossove...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2020
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201910086